Metabolic syndrome and its cardiovascular effects

The incidence of this syndrome in the Puerto Rican population is around 50%.

Metabolic syndrome is a very serious problem in our population. Photo: Shutterstock.

This number is very high when it is related to the premature development of disease cardiovascular, although the Puerto Rican population is protected by its genetic diversity. We recently discussed the minor incidence of coronary disease in our population, in a Program of “Gene-Med Corporation” and the institutes of health in Bethesda, Maryland, everything related to the diversity of genes.


The metabolic syndrome It is a very serious problem of our population. In the article published by Dr. José Marcial in “Obesity”, the data of a sample of obese, young patients, followed in the clinics of the University of Puerto Rico in the middle Cardiovascular from Puerto Rico and the Caribbean. These were patients between the ages of 21 to 35 years with myocardial infarctions. Most were male with major risk factors cardiovascular: obesity, smoking, hypertension and lipid abnormalities.


The analysis shows that obese patients had a 5.94% chance of developing coronary disease. In addition to the risk factors, we found that they have a greater chance of developing an inflammatory process than the normal population (30%). This process is detected with a test, the importance of which he recently described: “C-reactive protein ultra sensitive.” This occurs when internal fat cells are activated, producing “cytokines” that affect the arteries in the body, especially the coronary ones. The process is: Angiotensin II-Endothelin I Þ endothelial cell inflammation, Þneutrophil infiltration Þmonocytes Þ macrophages (altered) endothelial cell damage by cytokines) Þ macrophages-foam cells, arteriosclerotic plaques Þ infarcts.


This process has to stop. When presented, the best method is the use of “Simvastatins”, a drug used to reduce cholesterol and which is the most anti-inflammatory statin. It has to be used in high doses (> 40mg). Another method is to reduce “oxidative stress” with the use of Q-10, folic acid and high doses of Omega 3 or Omega 7. Lately the role of “T cells” in the inflammatory process has been emphasized. Possibly the preventive use of Simvastatin is correct.

This is crucial to reduce inflammation in the obese patient. Obesity has become the epidemic of the 20th century.

Type 2 diabetes: It is another component of metabolic syndrome. It is another of the epidemics of the 20th century. It is closely linked to obesity and other metabolic syndromes such as psoriasis. This syndrome is closely linked to the inflammatory process. For this reason, all Type 2 diabetic patients should know their inflammatory status with the “C-reactive protein” test.


If it is positive, it is known that the inflammatory process is active and that it will cause damage to the endothelial cells, producing the previously explained cascades, especially alterations in macrophages that will end in damage and production of “foam cells”, alterations in HDL (cholesterol good) and alterations in the vascular system. This condition is closely related to alterations in intracoronary angiotensin II and endothelin I levels, studies published by our group. The works published by Dr. De Mello, and yourselves, demonstrated the importance of this intracellular system, especially Angiotensin II. The future of molecular biology and genetic work will be based on isolated cells, corroborating the importance of the work of Dr. De Mello and collaborators on isolated myocytes.


It is very important to understand the problem of HDL (good cholesterol) and LDL (bad cholesterol). It must be understood that the values ​​of these vary by country. The normal values ​​in Puerto Rico They are very different from North Americans. The normal average of LDL in PR is 112mg/dl, however, there is less coronary disease on our Island. The Latin world is genetically different from the North American, especially the Anglo-Saxon world.

In February 2018 we will be presenting our data at the “American Federation of Medical Research” in New Orleans. The effect on the metabolic syndrome and in the community is not the same in North America as it is in Puerto Rico. An LDL of 120mg/dl is not the same in Puerto Rico than in North America. The explanation is genetic. Pay attention. HDL is mysterious, but it is important because it is anti-inflammatory. That’s why we see a significant increase in bariatric surgery. Bariatric surgery is partly inflammatory, the reason for the increase in HDL. Our data will be presented in New Orleans in 2018.


Our society has to be re-structured socially and economically, after understanding our genetics. It is a Latino genetic, not North American. We have to have a battle against Obesity, if not, the metabolic syndrome it will destroy us; and will destroy the budget of the Department of Health. It will be an obese society with psychological and medical problems that will be left with the budget of the Department of Health. Our leaders have to sit down and think about these medical issues. I think they are not doing it.

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