Diabetes drug metformin prolongs life and slows down aging

The study found that metformin, a first-line treatment for diabetes, not only lowers blood sugar levels, but also prolongs life.

A research team at the Massachusetts General Hospital in Boston, USA, has identified C. caenorhabditis elegans as a widely used model organism in cell biology, neuroscience, and aging studies because it corresponds to approximately 80% of human genes.

As a result of the lifespan study of C. In particular, it was found that the level of ester lipids of C. elegans exposed to metformin was significantly increased compared to the control group. Later, it was found that “Fard-1”, a fatty acid reductase involved in ester lipid biosynthesis, can also significantly increase the lifespan of C. elegans.

The research team said: “We have found that ester lipid levels are important as a novel indicator of healthy aging and life extension. However, further studies using mammalian models and human trials are needed.”

The study was recently published in the international journal eLife.

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